In 2006, LEGO released 2 Exclusive sets across 2 subthemes, all of these sets have been retired. Subthemes for that year included FIRST LEGO League and Photo Frames. For that year, the total price of all retail sets cost $75, today those sets are valued around $209, a growth of 179%.
Most valuable 2006 LEGO Exclusive set
9763 FIRST LEGO League Challenge 2006 Nano Quest $187.58
2 sets

9763 FIRST LEGO League Challenge 2006 Nano Quest

Theme / Subtheme Exclusive / FIRST LEGO League
Year 2006
Pieces / Minifigs 1,514 / 2
Availability Retired
9763 FIRST LEGO League Challenge 2006 Nano Quest
Retail $75.00
Value $187.58
Growth  +150.1%
Annual growth 4.7%

Holiday Picture Frame

Theme / Subtheme Exclusive / Photo Frames
Year 2006
Availability Retired
LEGO Holiday Picture Frame
promotional
Value $21.68
Annual growth 12.2%