The LEGO Friends Vet subtheme focuses on animal care and veterinary play scenarios set in Heartlake City, with waves dating back to 2015. Long-running sets include 41085 Vet Clinic, 41086 Vet Ambulance, and 41125 Horse Vet Trailer, followed by a 2021 refresh with 41446 Heartlake City Vet Clinic, 41445 Vet Clinic Ambulance, 41442 Vet Clinic Rescue Buggy, and 41692 Vet Clinic Rescue Helicopter. Recent releases include 42648 Panda Sanctuary Animal Care, 42654 Pony Ranch & Stable, and the 2026 42696 Animal Vet Clinic. The subtheme features animal mini-figures, treatment accessories, and rescue vehicles.