In 2010, LEGO released 39 Duplo sets across 8 subthemes, all of these sets have been retired. Subthemes for that year included Building Sets, Cars, Construction, Farm, Holiday, LEGO Ville, Toy Story, and Value Packs. For that year, the total price of all retail sets cost $987, today those sets are valued around $3,626, a growth of 268%.
Most valuable 2010 LEGO Duplo set
5650 Front Loader $299.12
Largest 2010 LEGO Duplo set
5511 XXL Box 201 pieces
Most owned 2010 Duplo set
5816 Mack's Road Trip
39 sets

5497 Play with Numbers

Theme Duplo
Year 2010
Pieces / Duplo figures 58 / 1
Availability Retired
5497 LEGO Duplo Play with Numbers
Retail $24.99
Value $36.15
Growth  +44.7%
Annual growth 2.2%

5506 Duplo Large Brick Box

Theme / Subtheme Duplo / Building Sets
Year 2010
Pieces / Duplo figures 71 / 1
Availability Retired
5506 LEGO Duplo Large Brick Box
Retail $29.99
Value $52.45
Growth  +74.9%
Annual growth 5.6%

5507 Duplo Deluxe Brick Box

Theme / Subtheme Duplo / Building Sets
Year 2010
Pieces / Duplo figures 102 / 2
Availability Retired
5507 LEGO Duplo Deluxe Brick Box
Retail $49.99
Value $257.32
Growth  +414.7%
Annual growth 6.1%

5509 Duplo Basic Bricks

Theme Duplo
Year 2010
Pieces 45
Availability Retired
5509 LEGO Duplo Basic Bricks
Retail $12.99
Value $161.82
Growth  +1145.7%
Annual growth 18.0%

5511 XXL Box

Theme / Subtheme Duplo / Building Sets
Year 2010
Pieces 201
Availability Retired
5511 LEGO Duplo XXL Box
Retail $29.99
Value $69.33
Growth  +131.2%
Annual growth 7.3%

5548 Duplo Building Fun

Theme / Subtheme Duplo / Building Sets
Year 2010
Pieces 81
Availability Retired
5548 LEGO Duplo Building Fun
Retail $29.99
Value $92.14
Growth  +207.2%
Annual growth 5.7%

5622 Duplo Basic Bricks Large

Theme Duplo
Year 2010
Pieces 60
Availability Retired
5622 LEGO Duplo Basic Bricks Large
Retail $19.99
Value $21.07
Growth  +5.4%

5643 Little Piggy

Theme / Subtheme Duplo / Farm
Year 2010
Pieces / Duplo figures 4 / 1
Availability Retired
5643 LEGO Duplo Farm Little Piggy
Retail $4.99
Value $25.55
Growth  +412.0%
Annual growth 4.9%

5644 Chicken Coop

Theme / Subtheme Duplo / Farm
Year 2010
Pieces / Duplo figures 11 / 1
Availability Retired
5644 LEGO Duplo Farm Chicken Coop
Retail $8.99
Value $23.68
Growth  +163.4%
Annual growth 6.4%

5645 Farm Bike

Theme / Subtheme Duplo / Farm
Year 2010
Pieces / Duplo figures 9 / 1
Availability Retired
5645 LEGO Duplo Farm Bike
Retail $9.99
Value $14.99
Growth  +50.1%
Annual growth 3.6%

5646 Farm Nursery

Theme / Subtheme Duplo / Farm
Year 2010
Pieces / Duplo figures 9 / 1
Availability Retired
5646 LEGO Duplo Farm Nursery
Retail $11.99
Value $40.77
Growth  +240.0%
Annual growth 5.0%

5647 Big Tractor

Theme / Subtheme Duplo / Farm
Year 2010
Pieces / Duplo figures 12 / 1
Availability Retired
5647 LEGO Duplo Farm Big Tractor
Retail $19.99
Value $44.95
Growth  +124.9%
Annual growth 5.9%

5648 Horse Stables

Theme / Subtheme Duplo / Farm
Year 2010
Pieces / Duplo figures 58 / 2
Availability Retired
5648 LEGO Duplo Farm Horse Stables
Retail $39.99
Value $98.52
Growth  +146.4%
Annual growth 4.4%

5649 Big Farm

Theme / Subtheme Duplo / Farm
Year 2010
Pieces / Duplo figures 68 / 3
Availability Retired
5649 LEGO Duplo Big Farm
Retail $59.99
Value $96.13
Growth  +60.2%
Annual growth 2.1%

5650 Front Loader

Theme / Subtheme Duplo / Construction
Year 2010
Pieces / Duplo figures 9 / 1
Availability Retired
5650 LEGO Duplo Construction Front Loader
Retail $12.99
Value $299.12
Growth  +2202.7%
Annual growth 10.2%

5651 Dump Truck

Theme / Subtheme Duplo / Construction
Year 2010
Pieces / Duplo figures 10 / 1
Availability Retired
5651 LEGO Duplo Construction Dump Truck
Retail $19.99
Value $59.59
Growth  +198.1%
Annual growth 6.1%

5652 Road Construction

Theme / Subtheme Duplo / Construction
Year 2010
Pieces / Duplo figures 27 / 2
Availability Retired
5652 LEGO Duplo Road Construction
Retail $39.99
Value $120.61
Growth  +201.6%
Annual growth 4.1%

5653 Stone Quarry

Theme / Subtheme Duplo / Construction
Year 2010
Pieces / Duplo figures 48 / 3
Availability Retired
5653 LEGO Duplo Construction Stone Quarry
Retail $59.99
Value $221.29
Growth  +268.9%
Annual growth 8.8%

5654 Fishing Trip

Theme / Subtheme Duplo / Holiday
Year 2010
Pieces / Duplo figures 14 / 2
Availability Retired
5654 LEGO Duplo Holiday Fishing Trip
Retail $14.99
Value $80.57
Growth  +437.5%
Annual growth 6.1%

5655 Caravan

Theme / Subtheme Duplo / Holiday
Year 2010
Pieces / Duplo figures 21 / 3
Availability Retired
5655 LEGO Duplo Holiday Caravan
Retail $29.99
Value $99.99
Growth  +233.4%
Annual growth 9.7%

5656 Pet Shop

Theme / Subtheme Duplo / LEGO Ville
Year 2010
Pieces / Duplo figures 29 / 2
Availability Retired
5656 Duplo LEGO Ville Pet Shop
Retail $24.99
Value $44.10
Growth  +76.5%
Annual growth 2.4%

5657 Jessie's Round-Up

Theme / Subtheme Duplo / Toy Story
Year 2010
Pieces / Duplo figures 18 / 1
Availability Retired
5657 LEGO Duplo Toy Story Jessie's Round-Up
Retail $14.99
Value $74.13
Growth  +394.5%
Annual growth 11.6%

5658 Pizza Planet Truck

Theme / Subtheme Duplo / Toy Story
Year 2010
Pieces / Duplo figures 13 / 2
Availability Retired
5658 LEGO Duplo Toy Story Pizza Planet Truck
Retail $19.99
Value $59.75
Growth  +198.9%
Annual growth 5.5%

5659 The Great Train Chase

Theme / Subtheme Duplo / Toy Story
Year 2010
Pieces / Duplo figures 39 / 3
Availability Retired
5659 LEGO Duplo Toy Story The Great Train Chase
Retail $34.99
Value $97.85
Growth  +179.7%
Annual growth 4.1%

5691 Alien Space Crane

Theme / Subtheme Duplo / Toy Story
Year 2010
Pieces / Duplo figures 23 / 3
Availability Retired
5691 LEGO Duplo Toy Story Alien Space Crane
Retail $39.99
Value $132.80
Growth  +232.1%
Annual growth 4.4%

5813 Lightning McQueen

Theme / Subtheme Duplo / Cars
Year 2010
Pieces / Duplo figures 11 / 1
Availability Retired
5813 LEGO Duplo Cars Lightning McQueen
Retail $14.99
Value $57.11
Growth  +281.0%
Annual growth 6.3%

5814 Mater's Yard

Theme / Subtheme Duplo / Cars
Year 2010
Pieces / Duplo figures 16 / 2
Availability Retired
5814 LEGO Duplo Cars Mater's Yard
Retail $19.99
Value $92.86
Growth  +364.5%
Annual growth 5.8%

5815 Flo's V-8 Cafe

Theme / Subtheme Duplo / Cars
Year 2010
Pieces / Duplo figures 32 / 3
Availability Retired
5815 LEGO Duplo Cars Flo's V-8 Cafe
Retail $29.99
Value $199.99
Growth  +566.9%
Annual growth 9.6%

5816 Mack's Road Trip

Theme / Subtheme Duplo / Cars
Year 2010
Pieces / Duplo figures 34 / 3
Availability Retired
5816 LEGO Duplo Cars Mack's Road Trip
Retail $49.99
Value $180.35
Growth  +260.8%
Annual growth 8.1%

30060 Farm Random Bag

Theme / Subtheme Duplo / Farm
Year 2010
Pieces / Duplo figures 4 / 1
Availability Retired
30060 LEGO Duplo Farm Random Bag
promotional
Value $4.93
Annual growth 5.5%

30060-2 Farm Farmer

Theme Duplo
Year 2010
Pieces / Duplo figures 3 / 1
Availability Retired
30060-2 LEGO Duplo Farm Farmer
promotional
Value $4.93
Annual growth 10.5%

30060-3 Farm Dog

Theme Duplo
Year 2010
Pieces 4
Availability Retired
30060-3 LEGO Duplo Farm Dog
promotional
Value $4.92
Annual growth 6.3%

30060-4 Farm Sheep

Theme Duplo
Year 2010
Pieces 4
Availability Retired
30060-4 LEGO Duplo Farm Sheep
promotional
Value $4.93
Annual growth 5.1%

30060-5 Farm Horse

Theme Duplo
Year 2010
Pieces 4
Availability Retired
30060-5 LEGO Duplo Farm Horse
promotional
Value $4.92
Annual growth 10.5%

30060-6 Farm Cow

Theme Duplo
Year 2010
Pieces 4
Availability Retired
30060-6 LEGO Duplo Farm Cow
promotional
Value $4.93
Annual growth 10.5%

66310 Duplo Value Pack

Theme / Subtheme Duplo / Value Packs
Year 2010
Availability Retired
66310 LEGO Duplo Value Pack
Retail $59.99
Value $188.79
Growth  +214.7%
Annual growth 7.4%

66344 Duplo Super Pack 4 in 1

Theme / Subtheme Duplo / Value Packs
Year 2010
Pieces 33
Availability Retired
66344 LEGO Duplo Super Pack 4 in 1
Retail $34.99
Value $164.77
Growth  +370.9%
Annual growth 10.2%

66367 Duplo Farm Pack

Theme / Subtheme Duplo / Value Packs
Year 2010
Pieces 68
Availability Retired
66367 LEGO Duplo Farm Pack
Retail $79.99
Value $286.66
Growth  +258.4%
Annual growth 8.3%

66384 Duplo Alltoys Co-Pack

Theme / Subtheme Duplo / Value Packs
Year 2010
Pieces 71
Availability Retired
66384 LEGO Duplo Alltoys Co-Pack
Retail $29.99
Value $101.53
Growth  +238.5%
Annual growth 7.9%