In 2000, LEGO released 4 Mindstorms sets across 2 subthemes, all of these sets have been retired. Subthemes for that year included 1 and Star Wars. For that year, the total price of all retail sets cost $300, today those sets are valued around $441, a growth of 47%.
Most valuable 2000 LEGO Mindstorms set
9754 Dark Side Developer Kit $184.21
4 sets

3801 Ultimate Accessory Set

Theme / Subtheme Mindstorms / 1
Year 2000
Pieces 45
Availability Retired
3801 LEGO Mindstorms Ultimate Accessory Set
Retail $49.99
Value $67.60
Growth  +35.2%
Annual growth 6.7%

9731 Vision Command

Theme / Subtheme Mindstorms / 1
Year 2000
Pieces 138
Availability Retired
9731 LEGO Mindstorms Vision Command
Retail $99.99
Value $108.59
Growth  +8.6%

9736 Exploration Mars

Theme / Subtheme Mindstorms / 1
Year 2000
Pieces 155
Availability Retired
9736 LEGO Mindstorms Exploration Mars
Retail $49.99
Value $80.51
Growth  +61.1%
Annual growth 7.8%

9754 Dark Side Developer Kit

Theme / Subtheme Mindstorms / Star Wars
Year 2000
Pieces 578
Availability Retired
9754 LEGO Mindstorms Star Wars Dark Side Developer Kit
Retail $99.99
Value $184.21
Growth  +84.2%
Annual growth 2.2%